McMMAF
McMMAF is a maleimidocaproyl-linked derivative of the cytotoxic agent MMAF, designed for the facile preparation of antibody-drug conjugates (ADCs) . This prodrug enables targeted delivery of the potent tubulin inhibitor for research in oncology, supporting both in vitro cytotoxicity studies and in vivo efficacy models of ADC therapeutics.
Product Specifications
CAS Number
863971-19-1
Product Name Alternative
DrugLinkerConjugatesforADC, DrugLinker Conjugates for ADC, Drug-Linker Conjugates for ADC, Auristatin, inhibit, Microtubule Associated, MicrotubuleAssociated, Inhibitor, McMMAF, Maleimidocaproyl monomethylauristatin F, tubulin polymerization
Field of Research
Cell Biology, Signal Transduction
Purity
99.65% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (5.4 mM) ; DMSO:100 mg/mL (108.09 mM)
Smiles
[C@H] ([C@H] (C (N[C@@H] (CC1=CC=CC=C1) C (O) =O) =O) C) (OC) [C@]2 (N (C (C[C@H] ([C@@H] (N (C ([C@@H] (NC ([C@@H] (N (C (CCCCCN3C (=O) C=CC3=O) =O) C) [C@@H] (C) C) =O) C (C) C) =O) C) [C@H] (CC) C) OC) =O) CCC2) [H]
Molecular Formula
C49H76N6O11
Molecular Weight
925.16
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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