Ivacaftor
Ivacaftor (VX-770) is a CFTR potentiator effective on G551D and F508del mutants, with EC50 values of 100 nM and 25 nM, respectively, in Fisher rat thyroid cell assays. It is a key research tool for studying CFTR channel function and rescue in cellular models of cystic fibrosis, supporting both in vitro and preclinical in vivo research.
Product Specifications
CAS Number
873054-44-5
Product Name Alternative
Inhibit, Ivacaftor, Ivacaftor (VX-770), G551D-CFTR, F508del-CFTR, Inhibitor, Autophagy, Cystic fibrosis transmembrane conductance regulator, CFTR, VX770, VX-770, VX 770
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
98.00% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:252 mg/mL (642.05 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (12.74 mM)
Smiles
C (C) (C) (C) C1=C (NC (=O) C=2C (=O) C=3C (NC2) =CC=CC3) C=C (O) C (C (C) (C) C) =C1
Molecular Formula
C24H28N2O3
Molecular Weight
392.49
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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