AF-353 (Standard)
AF-353 (Standard) is the analytical standard of AF-353. This product is intended for research and analytical applications. AF-353 (Ro-4) is a potent, selective and orally bioavailable P2X3/P2X2/3 receptor antagonist, with a pIC50 of 8.0 for both human and rat P2X3, and with a pIC50 of 7.3 for human P2X2/3[1][2].
Product Specifications
CAS Number
865305-30-2
UNSPSC
12352100
Target
P2X Receptor; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Cancer
Smiles
CC(C)C1=C(OC2=CN=C(N)N=C2N)C=C(I)C(OC)=C1
Molecular Formula
C14H17IN4O2
Molecular Weight
400.21
References & Citations
[1]Gever JR, et al. AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol. 2010 Jul;160 (6) :1387-1398.|[2]Munoz A, et al. Modulation of bladder afferent signals in normal and spinal cord-injured rats by purinergic P2X3 and P2X2/3receptors. BJU Int. 2012 Oct;110 (8 Pt B) :E409-414.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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