SB225002
SB225002 is a selective small molecule antagonist of the CXCR2 chemokine receptor, effectively blocking IL-8 binding. It is widely used in research to investigate CXCR2's role in neutrophil migration, inflammation, and cancer biology in both cellular and animal models.
Product Specifications
CAS Number
182498-32-4
Product Name Alternative
Inhibit, Inhibitor, CXCR2, CXCR, CXC chemokine receptors, SB 225002, SB225002, SB-225002
Field of Research
Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery
Purity
96.86% (May vary between batches)
Solubility
DMSO:71.4 mg/mL (202.76 mM) ; Ethanol:3 mg/mL (8.52 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.68 mM)
Smiles
N (C (NC1=C (Br) C=CC=C1) =O) C2=C (O) C=C (N (=O) =O) C=C2
Molecular Formula
C13H10BrN3O4
Molecular Weight
352.14
References & Citations
Yan-Hua Zhao, Juan Chen, Tao Gong, Hai-Yan Ge, Min Li Icariin inhibits tumor-associated neutrophil recruitment via the CXCL8-CXCR2 axis and restrains pro-metastatic programs in colorectal cancer WJG, 32 (11), 113325 (2026)
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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