Losartan Carboxylic Acid
Losartan Carboxylic Acid (E-3174) is the active metabolite of losartan and a highly potent AT1 receptor antagonist (Kis: 0.57 nM rat, 0.67 nM human) . It effectively inhibits angiotensin II-induced vasoconstriction, producing depressor and vasodilatory effects, making it a key tool for cardiovascular research in both in vitro and in vivo studies.
Product Specifications
CAS Number
124750-92-1
Product Name Alternative
Pressor, responses, smooth, vascular, anterior, angiotensin II, Angiotensin Receptor, AT1 receptor, E 3174, E3174, E-3174, cells, infarction, muscle, myocardial, Losartan Carboxylic Acid, inhibit, metabolite, EXP3174, EXP-3174, EXP 3174, Inhibitor
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Purity
98.36% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.58 mM) ; DMSO:70 mg/mL (160.22 mM)
Smiles
C (N1C (CCCC) =NC (Cl) =C1C (O) =O) C2=CC=C (C=C2) C3=C (C=CC=C3) C=4NN=NN4
Molecular Formula
C22H21ClN6O2
Molecular Weight
436.89
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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