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Nutlin-3a

Nutlin-3a is the biologically active enantiomer of Nutlin-3, functioning as a potent and selective MDM2 antagonist that disrupts the MDM2-p53 interaction. This stabilization and activation of p53 underpins its utility in cancer research, demonstrating antitumor activity in both cellular assays and in vivo models.

Product Specifications

CAS Number

675576-98-4

Product Name Alternative

Apoptosis, Autophagy, carcinomas, (-) -Nutlin-3, (−) -Nutlin-3, E1 activating enzyme, E2Enzyme, E3 Enzyme, E2 Enzyme, E2 conjugating enzyme, E1/E2/E3 Enzyme, E1 Enzyme, E1Enzyme, E3 ligating enzyme, E3Enzyme, Inhibitor, MDM-2/p53, inhibit, p53, p53/MDM2, Nutlin 3a, Nutlin-3, Nutlin3a, Nutlin-3a, Nutlin-3a chiral, ovarian, Rebemadlin, Ubiquitin ligase, Ubiquitin conjugating enzyme, Ubiquitin activating enzyme

Field of Research

Cell Biology, Protein Biochemistry

Purity

95.62% (May vary between batches)

Solubility

Ethanol:58.2 mg/mL (100.09 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.44 mM) ; DMSO:55 mg/mL (94.58 mM)

Smiles

COc1ccc (C2=N[C@H] ([C@H] (N2C (=O) N2CCNC (=O) C2) c2ccc (Cl) cc2) c2ccc (Cl) cc2) c (OC (C) C) c1

Molecular Formula

C30H30Cl2N4O4

Molecular Weight

581.49

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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