Neflamapimod
Neflamapimod (VX-745) is a potent and selective p38α MAPK inhibitor with an IC50 of 10 nM, demonstrating 22-fold selectivity over p38β and no activity against p38γ. It has been utilized in preclinical research to investigate p38α's role in neuroinflammation and synaptic dysfunction, with studies conducted in both cellular and animal models of neurodegenerative diseases.
Product Specifications
CAS Number
209410-46-8
Product Name Alternative
Autophagy, inhibit, Inhibitor, Neflamapimod, VX745, VX-745, VX 745, p38β, p38MAPK, p38α, p38 MAPK
Field of Research
Cell Biology, Signal Transduction
Purity
≥95% (May vary between batches)
Solubility
DMSO:43.6 mg/mL (99.94 mM)
Smiles
Fc1ccc (Sc2ccc3c (-c4c (Cl) cccc4Cl) c (=O) ncn3n2) c (F) c1
Molecular Formula
C19H9Cl2F2N3OS
Molecular Weight
436.26
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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