EPZ004777
EPZ004777 is a highly potent and selective inhibitor of the histone methyltransferase DOT1L, exhibiting an IC50 of 0.4 nM. This compound is a valuable chemical probe for studying histone H3K79 methylation in epigenetics research, with utility in both in vitro biochemical assays and in vivo models of MLL-rearranged leukemia.
Product Specifications
CAS Number
1338466-77-5
Product Name Alternative
Apoptosis, DOT1L, EPZ 004777, EPZ004777, EPZ-004777, HistoneMethyltransferase, Histone Methyltransferase, Inhibitor, inhibit
Field of Research
Cell Biology, Epigenetics & Chromatin
Purity
98.99% (May vary between batches)
Solubility
DMSO:54 mg/mL (100.06 mM) ; Ethanol:54 mg/mL (100.06 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.71 mM)
Smiles
CC (C) N (CCCNC (=O) Nc1ccc (cc1) C (C) (C) C) C[C@H]1O[C@H] ([C@H] (O) [C@@H]1O) n1ccc2c (N) ncnc12
Molecular Formula
C28H41N7O4
Molecular Weight
539.67
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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