VU0357017 hydrochloride
VU0357017 hydrochloride is a highly selective, allosteric agonist of the M1 muscarinic receptor with an EC50 of 477 ± 172 nM. This research compound is utilized in vitro and in vivo to investigate M1 receptor function in contexts such as cognitive disorders and central nervous system research.
Product Specifications
CAS Number
1135242-13-5
Product Name Alternative
Muscarinic acetylcholine receptor, muscarinic, inhibit, M1 mAChR, mAChR, ML071 hydrochloride, ML071 Hydrochloride, ML-071 Hydrochloride, ML 071 Hydrochloride, Inhibitor, CID25010775, CID-25010775, CID 25010775, acetylcholine, Alzheimer's, VU0357017, VU-0357017, VU0357017 Hydrochloride, VU0357017 hydrochloride, VU-0357017 Hydrochloride, VU-0357017 hydrochloride, VU 0357017, VU 0357017 hydrochloride, VU 0357017 Hydrochloride, schizophrenia
Field of Research
Neuroscience
Purity
99.00% (May vary between batches)
Solubility
DMSO:33 mg/mL (89.22 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.41 mM)
Smiles
Cl.CCOC (=O) N1CCC (CC1) NCCNC (=O) c1ccccc1C
Molecular Formula
C18H28ClN3O3
Molecular Weight
369.89
References & Citations
Paulina Cieślik 1, Anna Rafało-Ulińska 1, Joanna M Wierońska Prevention of MK-801-induced amnestic effect with combined activation of 5-HT1A and muscarinic receptors in mice Pharmacol Biochem Behav, (2024)
Pubmed id
38462045
Storage Conditions
-20°C
Notes
For research use only.
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