RSL3
RSL3 is a potent and selective ferroptosis inducer that functions by inhibiting GPX4 and system xc- (IC50=100 nM), thereby depleting glutathione. It effectively triggers cell death in oncogenic RAS-harboring tumor cells and is widely used in vitro and in vivo to study ferroptosis mechanisms in cancer research.
Product Specifications
CAS Number
1219810-16-8
Product Name Alternative
1S,3R-RSL3
Field of Research
Cell Biology, Neuroscience
Purity
>98%
Bioactivity
GPX4 Inhibitor / Ferroptosis inducer
Form
Powder
Solubility
Soluble in DMSO (up to 45 mg/ml)
Smiles
COC (=O) [C@H]1Cc2c ([nH]c3ccccc23) [C@@H] (N1C (=O) CCl) c1ccc (cc1) C (=O) OC
Molecular Formula
C23H21ClN2O5
Molecular Weight
440.9
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
(1S,3R) -Methyl 2- (2-chloroacetyl) -2,3,4,9-tetrahydro-1-[4- (methoxycarbonyl) phenyl]-1H-pyrido[3,4-b]indole-3-carboxylate
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