Macitentan
Macitentan (ACT-064992) is a dual endothelin receptor antagonist employed in pulmonary arterial hypertension (PAH) research. It is widely used in both in vitro binding assays and in vivo animal models to study endothelin signaling pathways and evaluate potential therapeutic interventions.
Product Specifications
CAS Number
441798-33-0
Product Name Alternative
Arterial, Apoptosis, ACT064992, ACT-064992, ACT 064992, Inhibitor, hypertension, idiopathic, endothelin, Endothelin Receptor, EndothelinReceptor, ET-B, ETB, ET-A, ETA, fibrosis, inhibit, non-peptide, orally, Macitentan, pulmonary
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
98.00% (May vary between batches)
Solubility
DMSO:93 mg/mL (158.09 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.61 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
N (S (NCCC) (=O) =O) C=1C (=C (OCCOC=2N=CC (Br) =CN2) N=CN1) C3=CC=C (Br) C=C3
Molecular Formula
C19H20Br2N6O4S
Molecular Weight
588.27
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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