SKLB-163
SKLB-163 is a small molecule that functions by downregulating RhoGDI, which leads to JNK-1 pathway activation and caspase-3 induction, while suppressing phosphorylated Akt and p44/42 MAPK. This mechanism supports its application in cancer research, particularly in studies of apoptosis and cell signaling in vitro.
Product Specifications
CAS Number
1255099-06-9
Product Name Alternative
P44/42 MAPK, SKLB 163, SKLB163, SKLB-163, RhoGDI, JNK1, caspase-3, Akt
Field of Research
Cell Biology, Protein Biochemistry, Signal Transduction
Purity
98.31% (May vary between batches)
Solubility
DMSO:247.5 mg/mL (609.73 mM)
Smiles
S (CC (NCC1=CC=CC=C1) =O) C2=NC=3C (S2) =CC (NC (CCl) =O) =CC3
Molecular Formula
C18H16ClN3O2S2
Molecular Weight
405.92
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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