EOC317
EOC317 (ACTB-1003) is an orally bioavailable small molecule inhibitor targeting FGFR1, VEGFR2, and Tie-2 kinases with IC50 values of 6, 2, and 4 nM, respectively. It is utilized in preclinical research to investigate angiogenesis and tumor growth in both cellular assays and animal models.
Product Specifications
CAS Number
939805-30-8
Product Name Alternative
ACTB 1003, ACTB1003, ACTB-1003, EOC 317, EOC317, EOC-317, Fibroblast growth factor receptor, FGFR, FGFR1, Inhibitor, inhibit, VEGFR2, VEGFR, Vascular endothelial growth factor receptor, Tie2, Tie-2
Field of Research
Cardiovascular Research, Signal Transduction
Purity
98.00% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (4.23 mM) ; DMSO:55 mg/mL (92.98 mM)
Smiles
COCc1c (CN2CCOCC2) n2ncnc (N) c2c1-c1ccc (NC (=O) Nc2cc (ccc2F) C (F) (F) F) c (F) c1
Molecular Formula
C27H26F5N7O3
Molecular Weight
591.53
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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