Aftin-4
Aftin-4 is a γ-secretase activator that selectively increases Aβ1-42 production. This small molecule induces acute Alzheimer's disease-like pathology, including hippocampal learning deficits and mitochondrial alterations in rodent models, making it a valuable tool for in vivo and in vitro research on amyloid toxicity and AD mechanisms.
Product Specifications
CAS Number
866893-90-5
Product Name Alternative
Abeta, Aftin 4, Aftin4, Aftin-4, b Amyloid, Amyloid-β, bAmyloid, BetaAmyloid, Beta Amyloid, Gammasecretase, Inhibitor, inhibit, γ secretase (Aβ42), β-amyloid peptide, βAmyloid, β Amyloid
Field of Research
Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology
Purity
98.51% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.43 mM) ; DMSO:55 mg/mL (149.26 mM)
Smiles
CC[C@H] (CO) Nc1nc (N (C) Cc2ccccc2) c2ncn (C (C) C) c2n1
Molecular Formula
C20H28N6O
Molecular Weight
368.48
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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