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ML221

ML221 is a potent functional antagonist of the apelin/APJ system, inhibiting apelin-13-induced signaling with IC50 values of 0.70 μM (cAMP) and 1.75 μM (β-arrestin) . This compound is a valuable research tool for investigating the APJ receptor's role in cardiovascular function and metabolic diseases in both cellular and animal models.

Product Specifications

CAS Number

877636-42-5

Product Name Alternative

ML221, ML-221, ML 221, inhibit, Inhibitor, APJ, Apelin receptor, Apelinreceptor

Field of Research

Pharmacology & Drug Discovery

Purity

97.74% (May vary between batches)

Solubility

DMSO:6.25 mg/mL (16.22 mM)

Smiles

[O-][N+] (=O) c1ccc (cc1) C (=O) Oc1coc (CSc2ncccn2) cc1=O

Molecular Formula

C17H11N3O6S

Molecular Weight

385.35

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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