ARV-771
ARV-771 is a potent PROTAC-based degrader of BET proteins, exhibiting high affinity for BRD2, BRD3, and BRD4 bromodomains with Kd values in the single-digit nanomolar range. This compound is a valuable chemical probe for investigating BET protein function in cancer research, demonstrating efficacy in both cellular assays and in vivo tumor models.
Product Specifications
CAS Number
1949837-12-0
Product Name Alternative
Inhibit, EpigeneticReaderDomain, Epigenetic Reader Domain, Inhibitor, ARV 771, ARV771, ARV-771, BET, PROTACs
Field of Research
Epigenetics & Chromatin, Pharmacology & Drug Discovery
Purity
99.69% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.03 mM) ; DMSO:10 mM
Smiles
CC=1C2=C (N3C ([C@H] (CC (NCCOCCCOCC (N[C@H] (C (=O) N4[C@H] (C (N[C@@H] (C) C5=CC=C (C=C5) C=6SC=NC6C) =O) C[C@@H] (O) C4) C (C) (C) C) =O) =O) N=C2C7=CC=C (Cl) C=C7) =NN=C3C) SC1C
Molecular Formula
C49H60ClN9O7S2
Molecular Weight
986.64
Storage Conditions
-20°C
Notes
For research use only.
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