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Tasquinimod

Tasquinimod (ABR-215050) is an orally active small molecule with antiangiogenic and antitumor properties. It functions as an S100A9 inhibitor and binds the HDAC4 Zn2+ domain with high affinity (Kd 10-30 nM) . This agent has been investigated in preclinical in vivo models for cancers like prostate carcinoma and in vitro for immunomodulatory effects.

Product Specifications

CAS Number

254964-60-8

Product Name Alternative

ABR215050, ABR-215050, ABR 215050, inhibit, HDAC4, HDAC, Inhibitor, Histone deacetylases, Tasquinimod

Field of Research

Epigenetics & Chromatin, Molecular Biology

Purity

98.30% (May vary between batches)

Solubility

2% DMSO+40% PEG300+5% Tween-80+53% Saline:1 mg/mL (2.46 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:9 mg/mL (22.15 mM) ; DMSO:65 mg/mL (159.96 mM)

Smiles

COc1cccc2n (C) c (=O) c (C (=O) N (C) c3ccc (cc3) C (F) (F) F) c (O) c12

Molecular Formula

C20H17F3N2O4

Molecular Weight

406.36

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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