Fumonisin B1

Ceramide synthase inhibitor

Product Specifications

Background

Fumonisin B1 is the most prevalent member of a family of toxins. It is hepatotoxic and nephrotoxic in all animal species. It occupies the space and electrostatic interactions of both sphinganine and fatty acyl-CoA (1). Due to this mechanism of action, it has toxic effects in humans such as neural tube defects (2), esophageal cancer, acute mycotoxicosis, and various other carcinogenic effects. Another effect of exposure to FB1 is apoptosis (2).

Product Name Alternative

2,2'-{(19-Amino-11,16,18-trihydroxy-5,9-dimethyl-6,7-icosanediyl)bis[oxy(2-oxo-2,1-ethanediyl)]}disuccinic acid

UNSPSC

41116105

Source

Synthetic

Purity

>98%

Weight

0.001

Format

Beige Solid

Solubility

Soluble to 10 mM in DMSO

Molecular Formula

C34H59NO15

Molecular Weight

721.83

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. European commission (2007). “Fumonisin B1”. Opinion of the scientific committee on food on Fusarium toxins (27). 2. Stockmann-Juvalla H., and Savolainen K. (2008) Human and Exp. Toxicology. 27: 799-809.