RS-127445
RS-127445 (MT500) is a potent and highly selective 5-HT2B receptor antagonist, with a pKi of 9.5 and a pIC50 of 10.4, demonstrating over 1000-fold selectivity versus other serotonin receptors. This tool compound is widely used in cardiovascular and fibrotic disease research, facilitating both in vitro binding assays and in vivo pharmacological studies.
Product Specifications
CAS Number
199864-87-4
Product Name Alternative
5-HT2B, 5HT Receptor, 5-HT Receptor, 5-hydroxytryptamine Receptor, 5HTReceptor, inhibit, MT 500, MT500, MT-500, Inhibitor, Serotonin Receptor, RS 127445, RS127445, RS-127445
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
98.81% (May vary between batches)
Solubility
Ethanol:8 mg/mL (28.44 mM) ; DMSO:52 mg/mL (184.84 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.55 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
CC (C) c1cc (nc (N) n1) -c1ccc (F) c2ccccc12
Molecular Formula
C17H16FN3
Molecular Weight
281.33
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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