SR-4835
SR-4835 is a potent and selective dual inhibitor of CDK12 (IC50=99 nM) and CDK13 (Kd=4.9 nM) . It has been shown to impair the growth and viability of triple-negative breast cancer (TNBC) cells in vitro, providing a valuable chemical probe for oncology research targeting transcriptional CDKs.
Product Specifications
CAS Number
2387704-62-1
Product Name Alternative
Cyclin dependent kinase, CDK, Apoptosis, Inhibitor, inhibit, SR4835, SR-4835, SR 4835
Field of Research
Cell Biology
Purity
98.00% (May vary between batches)
Solubility
DMSO:4.8 mg/mL (9.61 mM)
Smiles
Cn1cc (cn1) -n1cnc2c (NCc3nc4cc (Cl) c (Cl) cc4[nH]3) nc (nc12) N1CCOCC1
Molecular Formula
C21H20Cl2N10O
Molecular Weight
499.36
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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