JNJ-63576253 free base
JNJ-63576253 (TRC253) is a potent, orally bioavailable full antagonist of both wild-type and F877L mutant androgen receptor (AR), with IC50 values of 54 nM and 37 nM, respectively, in cellular assays. It is a research compound for studying castration-resistant prostate cancer (CRPC), demonstrating activity in relevant in vivo models.
Product Specifications
CAS Number
2110426-27-0
Field of Research
Metabolism Research
Purity
98.32% (May vary between batches)
Smiles
FC (F) (F) c1cc (cnc1C#N) N1C (=S) N (c2ccc (OC3CCNCC3) nc2) C2 (CCC2) C1=O
Molecular Formula
C23H21F3N6O2S
Molecular Weight
502.51
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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