VU 0240551
VU 0240551 is a selective, small-molecule antagonist of the neuronal K-Cl cotransporter KCC2, exhibiting an IC50 of 560 nM. It also demonstrates off-target activity by inhibiting L-type calcium channels and the hERG potassium channel. This compound is utilized in neuroscience research to investigate GABAergic signaling, neuronal excitability, and related pathophysiology in both cellular and animal models.
Product Specifications
CAS Number
893990-34-6
Product Name Alternative
HERG, L-type calcium channel, KCC2, Calcium Channel, CalciumChannel, PotassiumChannel, Potassium Channel, VU0240551, VU-0240551, VU 0240551
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Purity
99.72% (May vary between batches)
Solubility
H2O:Insoluble; DMSO:45 mg/mL (131.41 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.84 mM)
Smiles
S (CC (NC=1SC=C (C) N1) =O) C2=CC=C (N=N2) C3=CC=CC=C3
Molecular Formula
C16H14N4OS2
Molecular Weight
342.44
Storage Conditions
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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