PVRIG Recombinant Protein
Product Specifications
Background
Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The CD112R gene encodes a putative single transmembrane protein, which is composed of a single extracellular IgV domain, one transmembrane domain, and a long intracellular domain. Notably, the intracellular domain of phatases. The extracellular domain sequence of human and mouse CD112R have 65.3% similarity. CD112R may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.
NCBI Gene ID
79037
Swiss Prot
Q6DKI7
Accession Number
NP_076975.2
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>90% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-341
Calculated Molecular Weight
40.1 kDa
Applications Notes
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.1 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
PVR related immunoglobulin domain containing
NCBI Organism
Homo sapiens
Background Reference 01
Xu F., et.al. 2017, Cancer Immunol Immunother., 66 (10), 1367-1375.
Background Reference 02
Zhu, Y., et.al. 2016, J. Exp. Med., 213,167-76.
Other Product Names
C7orf15, C7orf15MGC138295, CD112R, MGC104322, MGC138297, MGC2463, PVRIG, CD112 receptor
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
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