GSK199
GSK199 is a potent and selective inhibitor of peptidyl arginine deiminase 4 (PAD4), exhibiting an IC50 of 200 nM under calcium-free conditions. This small molecule is a valuable research tool for studying PAD4's role in chromatin decondensation, neutrophil extracellular trap (NET) formation, and its implications in autoimmune diseases and cancer in both cellular and animal models.
Product Specifications
CAS Number
1549811-53-1
Product Name Alternative
Inhibitor, GSK 199, GSK199, GSK-199, inhibit, PAD4, Peptidylarginine Deiminase, Protein Arginine Deiminase
Field of Research
Epigenetics & Chromatin
Purity
98.09% (May vary between batches)
Solubility
DMSO:11 mg/mL (23.46 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (2.13 mM)
Smiles
Cl.CCn1c (cc2cccnc12) -c1nc2cc (cc (OC) c2n1C) C (=O) N1CCC[C@@H] (N) C1
Molecular Formula
C24H29ClN6O2
Molecular Weight
468.98
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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