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Crizotinib hydrochloride

Crizotinib hydrochloride (PF-02341066 hydrochloride) is a potent small molecule inhibitor targeting anaplastic lymphoma kinase (ALK) and c-Met with IC50 values of 20 nM and 8 nM, respectively. It is widely used in preclinical research for investigating non-small cell lung cancer and other malignancies, demonstrating efficacy in both cellular assays and animal models.

Product Specifications

CAS Number

1415560-69-8

Product Name Alternative

PF02341066, PF-02341066 hydrochloride, PF-02341066, PF02341066 Hydrochloride, PF-02341066 Hydrochloride, PF 02341066, PF 02341066 Hydrochloride, ROS, ROSKinase, ROS Kinase, inhibit, Inhibitor, HGFR, Crizotinib, Crizotinib Hydrochloride, Crizotinib hydrochloride, c-Met, cMet/HGFR, cMet, c-Met/HGFR, CD246, Cluster of differentiation 246, Anaplastic lymphoma kinase, Anaplastic lymphoma kinase (ALK), Autophagy, ALK tyrosine kinase receptor, ALK

Field of Research

Cardiovascular Research, Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction

Purity

98.73% (May vary between batches)

Solubility

DMSO:10 mg/mL (20.54 mM) ; H2O:50 mg/mL (102.71 mM)

Smiles

Cl.C[C@@H] (Oc1cc (cnc1N) -c1cnn (c1) C1CCNCC1) c1c (Cl) ccc (F) c1Cl

Molecular Formula

C21H23Cl3FN5O

Molecular Weight

486.8

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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