PF-04418948
PF-04418948 (PF 04418948) is a novel potent and selective prostaglandin EP2 receptor antagonist; inhibits prostaglandin E (2) (PGE (2) ) -induced increase in cAMP in cells with a functional K (B) value of 1.8 nM; attenuates the butaprost-induced cutaneous blood flow response in rats; orally active. (In Vitro) :PF-04418948 (2 μM; 90 min) inhibits prostaglandin E2 (PGE2) -induced increase in cAMP. (In Vivo) :PF-04418948 (oral gavage; 1, 3, and 10 mg/kg; once) attenuats the butaprost-induced cutaneous blood flow response.
Product Specifications
CAS Number
1078166-57-0
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
COC1=CC2=C (C=C1) C=C (C=C2) OCC3 (CN (C3) C (=O) C4=CC=C (C=C4) F) C (=O) O
Molecular Formula
C23H20FNO5
Molecular Weight
409.407
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3-Azetidinecarboxylic acid, 1- (4-fluorobenzoyl) -3-[[ (6-methoxy-2-naphthalenyl) oxy]methyl]-
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