I-CBP112
A specific and potent inhibitor of CBP/p300 bromodomain with Kd of 150-170 nM; displaces H3K56ac from the CBP binding site with an IC50 of 170 nM; demonstrates 37-fold and 132-fold selectivity over BRD4 BD1 and BRD4 BD2, respectively; increases the cytotoxic activity of JQ1 in leukemic cells; impaires the disease-initiating self-renewal leukemic cells in vitro and in vivo without causing significant cytotoxicity.
Product Specifications
CAS Number
1640282-31-0
Product Name Alternative
I-CBP112 | I-CBP-112 | I-CBP 112
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 32 mg/mL
Smiles
CCC (N1CCOC2=C (OC[C@@H]3CN (C) CCC3) C=C (C4=CC=C (OC) C (OC) =C4) C=C2C1) =O
Molecular Formula
C27H36N2O5
Molecular Weight
468.5851
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-Propanone, 1-[7- (3,4-dimethoxyphenyl) -2,3-dihydro-9-[[ (3S) -1-methyl-3-piperidinyl]methoxy]-1,4-benzoxazepin-4 (5H) -yl]-
Available Sizes
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