MZ1
MZ1 is a PROTAC that tethers JQ1 to a ligand for the E3 ubiquitin ligase VHL, triggers, induces degradation of the BET bromodomain BRD4; induces reversible, long-lasting, and unexpectedly selective removal of BRD4 over BRD2 and BRD3.
Product Specifications
CAS Number
1797406-69-9
Product Name Alternative
MZ-1 | MZ 1
Purity
>98% (HPLC)
Solubility
DMSO : 25 mg/mL 24.93 mM; H2O : < 0.1 mg/mL
Smiles
O=C ([C@H]1N (C ([C@@H] (NC (COCCOCCOCCNC (C[C@H]2C3=NN=C (C) N3C4=C (C (C) =C (C) S4) C (C5=CC=C (Cl) C=C5) =N2) =O) =O) C (C) (C) C) =O) CCC1) NCC6=CC=C (C7=C (C) N=CS7) C=C6
Molecular Formula
C49H60ClN9O8S2
Molecular Weight
1002.644
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(2S,4R) -1- ((S) -2- (tert-butyl) -17- ((S) -4- (4-chlorophenyl) -2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl) -4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl) -4-hydroxy-N- (4- (4-methylthiazol-5-yl) benzyl) pyrrolidine-2-carboxamide
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