MKT-077
MKT-077 (FJ-776) is a highly water-soluble (>200 mg/ml) rhodacyanine dye that exhibits significant antitumor activity, binds to Hsp70 family member, mortalin (mot-2), and abrogates its interactions with p53; induces release of wild-type p53 from cytoplasmically sequestered p53-mot-2 complexes and rescued its transcriptional activation function; also is a potent telomerase inhibitor with IC50 of 5 uM.
Product Specifications
CAS Number
147366-41-4
Product Name Alternative
FJ-776
Purity
>98% (HPLC)
Solubility
DMSO: 20 mg/mL; Water: 20 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C1N (CC) /C (S/C1=C2SC3=CC=CC=C3N/2C) =C/C4=CC=CC=[N+]4CC.[Cl-]
Molecular Formula
C21H22ClN3OS2
Molecular Weight
432
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Pyridinium, 1-ethyl-2-[[3-ethyl-5- (3-methyl-2 (3H) -benzothiazolylidene) -4-oxo-2-thiazolidinylidene]methyl]-, chloride (9CI)
Available Sizes
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