VR-23
A potent inhibitor of trypsin-like proteasome (IC50=1 nM), chymotrypsin-like proteasome (IC50=50-100 nM) and caspase-like proteasome (IC50=3 uM) ; targets the β2 of the 20S proteasome catalytic subunit and structurally distinct from other known proteasome inhibitors and selectively kills cancer cells by apoptosis, with little effect on noncancerous cells.
Product Specifications
CAS Number
1624602-30-7
Product Name Alternative
VR23
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=S (N1CCN (C2=CC=NC3=CC (Cl) =CC=C32) CC1) (C4=C (C=C (C=C4) [N+] ([O-]) =O) [N+] ([O-]) =O) =O
Molecular Formula
C19H16ClN5O6S
Molecular Weight
477.8782
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Quinoline, 7-chloro-4-[4-[ (2,4-dinitrophenyl) sulfonyl]-1-piperazinyl]-
Available Sizes
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