ZL0420
ZL0420 is a potent, highly selective BRD4 inhibitor with IC50 of 27 and 32 nM for BRD4-BD1 and BRD4-BD2, respectively; displays selectivity over BRD2, BRD3, and BRDT (BRD2-BD1 and BRD2-BD2, IC50=803 and 1736 nM) ; disrupts the BRD4 complex with Pol II and histones, inhibits poly (I:C) -induced expression of innate immune genes IL6 and CIG5 in human small airway epithelial cells (hSAECs) (IC50=0.54 and 0.51 uM) ; blocks Poly (I:C) -induced inflammation and neutrophilia in vivo.
Product Specifications
CAS Number
2229039-45-4
Product Name Alternative
ZL-0420 | ZL 0420
Purity
>98% (HPLC)
Smiles
CC1=C (O) C=C (N) C (/N=N/C2=CC (CCC (N3) =O) =C3C=C2) =C1
Molecular Formula
C16H16N4O2
Molecular Weight
296.33
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(E) -6- ((2-amino-4-hydroxy-5-methylphenyl) diazenyl) -3,4-dihydroquinolin-2 (1H) -one
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