LDN-27219

LDN-27219 is a reversible, slow-binding inhibitor of TGase. LDN-27219 inhibits human TGase with an IC50 value of 0.6 μM. LDN-27219 effectively decreases blood pressure and induces vasodilation, it can be used for the research of cardiovascular disease[1][2].

Product Specifications

CAS Number

[312946-37-5]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Glutaminase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/LDN-27219.html

Purity

99.64

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N(C2=CC=CC=C2)C(SCC(NN)=O)=NC3=C1C(C4=CC=CC=C4)=CS3

Molecular Formula

C20H16N4O2S2

Molecular Weight

408.50

Precautions

H315, H319, H335

References & Citations

[1]Case A, et al. Kinetic analysis of the interaction of tissue transglutaminase with a nonpeptidic slow-binding inhibitor. Biochemistry. 2007 Jan 30;46 (4) :1106-15.|[2]Pinilla E, et al. Transglutaminase 2 Inhibitor LDN 27219 Age-Dependently Lowers Blood Pressure and Improves Endothelium-Dependent Vasodilation in Resistance Arteries. Hypertension. 2021 Jan;77 (1) :216-227.