Tolnaftate
Tolnaftate is a synthetic thiocarbamate used as an anti-fungal agent. (In Vitro) :Tolnaftate (NP-27) blocked sterol biosynthesis in fungal cells and cell extracts, with accumulation of squalene. This point of action was confirmed by the direct inhibition of microsomal squalene epoxidase from Candida albicans. Tolnaftate (NP-27) inhibited sterol biosynthesis, At 100 microM, tolnaftate caused up to a 30% release of intracellular [14C]aminoisobutyric acid.
Product Specifications
CAS Number
2398-96-1
Product Name Alternative
NSC 233648 | SCH 10144
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 62 mg/mL (201.68 mM)
Smiles
S=C (OC1=CC=C2C=CC=CC2=C1) N (C) C3=CC=CC (C) =C3
Molecular Formula
C19H17NOS
Molecular Weight
307.42
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
O-naphthalen-2-yl N-methyl-N- (3-methylphenyl) carbamothioate
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