P-Cresyl sulfate (potassium) (Standard)

P-Cresyl sulfate (potassium) (Standard) is the analytical standard of p-Cresyl sulfate (potassium) . This product is intended for research and analytical applications. p-Cresyl sulfate (p-Tolyl sulfate) potassium is a uremic toxin, that can cause renal damage and dysfunction. p-Cresyl sulfate potassium shows antiproliferation activity. p-Cresyl sulfate potassium increases the protein expression of HIF-1α and VHL, decreases the protein expression of HIF-2α. p-Cresyl sulfate potassium induces epithelial-mesenchymal transition (EMT) . p-Cresyl sulfate potassium activates the JNK and p38 MAPK signaling pathways[1][2][3].

Product Specifications

CAS Number

[91978-69-7]

UNSPSC

12352100

Target

JNK; p38 MAPK; Reactive Oxygen Species (ROS) ; Reference Standards

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Metabolic Disease

Purity

99.88

Smiles

O=S(OC1=CC=C(C)C=C1)(O[K])=O

Molecular Formula

C7H7KO4S

Molecular Weight

226.29

References & Citations

[1]Wu TK, et al. The uremic toxin p-cresyl sulfate induces proliferation and migration of clear cell renal cell carcinoma via microRNA-21/ HIF-1α axis signals. Sci Rep. 2019 Mar 1;9 (1) :3207.|[2]Koppe L, et al. p-Cresyl sulfate promotes insulin resistance associated with CKD. J Am Soc Nephrol. 2013 Jan;24 (1) :88-99.|[3]Tanaka H, et al. p-Cresyl sulfate induces osteoblast dysfunction through activating JNK and p38 MAPK pathways. Bone. 2013 Oct;56 (2) :347-54.