MCC950 sodium
MCC950 (CP-456773) is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively, specifically inhibits activation of NLRP3, does not inhibit NLRC4, AIM2, TLR signalling or priming of NLRP3; blocks NLRP3 induced ASC oligomerization, does not block K+ efflux, Ca2+ flux or NLRP3-ASC interactions; reduces interleukin-1β (IL-1β) production in vivo and attenuates the severity of experimental autoimmune encephalomyelitis (EAE), rescues neonatal lethality in mouse model of CAPS and is active in ex vivo samples from individuals with Muckle-Wells syndrome.
Product Specifications
CAS Number
256373-96-3
Product Name Alternative
CP-456773 sodium | CRID3 sodium salt | MCC-950 sodium | CP456773 sodium | CRID-3 sodium salt
Purity
>98% (HPLC)
Solubility
H2O: ≥ 30 mg/mL
Smiles
CC (C) (C1=COC (=C1) S (=O) (=O) [N-]C (=O) NC2=C3CCCC3=CC4=C2CCC4) O.[Na+]
Molecular Formula
C20H23N2NaO5S
Molecular Weight
426.4618
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Furansulfonamide, N-[[ (1,2,3,5,6,7-hexahydro-s-indacen-4-yl) amino]carbonyl]-4- (1-hydroxy-1-methylethyl) -, sodium salt (1:1)
Available Sizes
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