IC-87114
A potent and selective PI3Kδ inhibitor with IC50 of 0.5 uM; displays 58-fold selectivity over PI3Kγ, and >100-fold over PI3Kα and PI3Kβ; inhibits polarized morphology of neutrophils, fMLP-stimulated PIP3 production and chemotaxis; inhibits constitutive phosphorylation of Akt/PKB and suppresses AML cell proliferation; reduces vascular permeability in a murine model of asthma.
Product Specifications
CAS Number
371242-69-2
Product Name Alternative
IC87114 | IC 87114
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C1N (C2=CC=CC=C2C) C (CN3C=NC4=C (N) N=CN=C34) =NC5=C1C (C) =CC=C5
Molecular Formula
C22H19N7O
Molecular Weight
397.4326
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4 (3H) -Quinazolinone, 2-[ (6-amino-9H-purin-9-yl) methyl]-5-methyl-3- (2-methylphenyl) -
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