ALDH1A1-IN-3
ALDH1A1-IN-3 (compound 57) is an excellent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor with an IC50 value of 0.379 μM. ALDH1A1-IN-3 can effectively improve glucose consumption in HepG2 cells. ALDH1A1-IN-3 can be used for researching glucose metabolism improvement[1].
Product Specifications
CAS Number
2439177-97-4
UNSPSC
12352005
Target
Aldehyde Dehydrogenase (ALDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/aldh1a1-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCN(CC1)CCC(N(CC2=CC=CC(C(F)(F)F)=C2)C3=CN(C)C(N(C)C3=O)=O)=O)C4=CC=C(C(C)C)C=C4
Molecular Formula
C31H36F3N5O4
Molecular Weight
599.64
References & Citations
[1]Ma Z, et al. Design, synthesis of 1,3-dimethylpyrimidine-2,4-diones as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity. Bioorg Chem. 2020 Aug;101:103971.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ALDH1
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