PI-103
A potent, dual class I PI3K/mTOR inhibitor with IC50 of 2/3/3/15/ for p110α/β/δ/γ, respectively; also inhibits TORC1 (>80% inhibition at 0.5 uM) and DNA-PK (IC50=14 nM), 15- to 20-fold less activity against class II PI3K C2β (IC50=43 nM), >1,300-fold selectivity over the class III PI3K Vsp34; potently inhibits proliferation and invasion of a wide variety of human cancer cells in vitro; shows activity in cancer xenograft models.
Product Specifications
CAS Number
371935-74-9
Product Name Alternative
PI 103 | PI103
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
OC1=CC (=CC=C1) C1=NC2=C (OC3=C2C=CC=N3) C (=N1) N1CCOCC1 |c:3,5,13,16,18,21, t:1,8,10|
Molecular Formula
C19H16N4O3
Molecular Weight
348.3553
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Phenol, 3-[4- (4-morpholinyl) pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]-
Available Sizes
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