Ribostamycin sulfate

Ribostamycin is a broad-spectrum antimicrobial, inhibits bacterial protein synthesis at the level of 30S and 50S ribosomal subunit binding, also inhibits the chaperone activity of protein disulfide isomerase (PDI), used in pharmacokinetic and nephrotoxicity studies. (In Vitro) :Ribostamycin is as an intermediate in the biosynthesis of neomycin.Ribostamycin inhibited the chaperone activity of protein disulfide isomerase (PDI), but it did not inhibit the isomerase activity.Ribostamycin is effective against both gram-positive and gram-negative cocci and bacilli including drug-resistant strains. Ribostamycin is especially effective against the gentamicin-resistant bacterium Klebsiella pneumoniae, which possesses aminoglycoside-modifying enzymes.