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Recombinant Human BCL2 Protein (GST Tag)

Product Specifications

Background

BCL2-like 12 (BCL2L12) is a new member of the apoptosis-related BCL2 gene family, members of which are implicated in various malignancies. The mRNA expression of BCL2L12 may constitute a novel biomarker for the prediction of short-term relapse in nasopharyngeal carcinoma. BCL2L12 is a recently identified gene belonging to the BCL2 family, members of which are implicated in hematologic malignancies, including chronic lymphocytic leukemia (CLL) . BCL2L12 can be considered as a new independent prognostic and chemotherapy response marker in AML. BCL2L12 mRNA expression may serve as a potential prognostic biomarker in tongue and/or larynx SCC, which principally constitute the great majority of HNSCC cases worldwide. BCL2L12 mRNA expression is a favorable prognostic marker of DFS for BC patients, suggesting its possible application as a novel prognostic indicator of this malignancy.

Abbreviation

BCL2

Synonyms

B-cell Lymphoma; PPP1R; BCL; Bcl-2; PPP1R50; BCL2; apoptosis regulator Bcl-2; B-cell Lymphoma 2; apoptosis regulator Bcl-2; Bcl-2; PPP1R50; Apoptosis regulator Bcl 2; Apoptosis regulator Bcl2; AW986256; B cell CLL/lymphoma 2; B cell leukemia/lymphoma 2; B-cell; C430015F12Rik; D630044D05Rik; D830018M01Rik; Leukemia/lymphoma; Oncogene B-cell leukemia 2; Protein phosphatase 1; regulatory subunit 50; Bcl2

UniProt

P10415

Accession Number

P10415

Expression System

E.coli

Tag

N-GST

Sequence

Met1-Asp211

Field of Research

Cancer; Cell Biology; Signal Transduction

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method

Purity

> 95% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

49.2 kDa

Observed Molecular Weight

50 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Species

Human

Available Sizes

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