Afatinib dimaleate
An irreversible, dual EGFR/HER2 inhibitor with IC50 of 0.5/0.4/10/14 nM for wt EGFR/EGFR L858R/EGFR L858R+T790M/HER2 respectively; shows high selectivity over HGFR, c-Src, β-InsRK, VEGFR2; suppresses transformation in isogenic cell-based assays, inhibits survival of cancer cell lines and induces tumor regression in xenograft and transgenic lung cancer models.Lung Cancer Approved.
Product Specifications
CAS Number
850140-73-7
Product Name Alternative
BIBW 2992MA2 | BIBW-2992 | BIBW2992 | BIBW 2992 | Afatinib
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 35 mg/mL
Smiles
CN (C/C=C/C (=O) NC1=C (C=C2N=CN=C (C2=C1) NC3=CC (=C (C=C3) F) Cl) O[C@@H]4COCC4) C.C (=C\C (=O) O) \C (=O) O.C (=C\C (=O) O) \C (=O) O
Molecular Formula
C32H33ClFN5O11
Molecular Weight
718.0827
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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