Brivanib
A dual inhibitor of VEGFR2 and FGFR1 with IC50 of 25 nM and 148 nM respectively; shows weak activity for VEGFR1 (IC50=380 nM), and no significant activity on EGFR, PDGFRβ, Lck, etc.; demonstrates robust in vivo activity in human tumor xenograft models.Liver Cancer Phase 3 Clinical.
Product Specifications
CAS Number
649735-46-6
Product Name Alternative
BMS-540215 | BMS540215 | BMS 540215
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 50 mg/mL
Smiles
FC1=C (OC2=NC=NN3C2=C (C (OC[C@H] (O) C) =C3) C) C=CC4=C1C=C (C) N4
Molecular Formula
C19H19FN4O3
Molecular Weight
370.3776
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Propanol, 1-[[4-[ (4-fluoro-2-methyl-1H-indol-5-yl) oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-, (2R) -
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