HLCL-61 hydrochloride
A novel potent and selective protein arginine methyltransferase PRMT5 inhibitor; shows no inhibitory activity against the type I (PRMT1 and PRMT4) and type II (PRMT7) PRMT family members; exhibits effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples, significantly increases expression of miR-29b and consequent suppression of Sp1 and FLT3 in AML cells; inhibits the proliferation of AML cell lines and primary blasts with IC50 of 7.21-21.46 uM.
Product Specifications
CAS Number
1158279-20-9
Product Name Alternative
HLCL61 hydrochloride | HLCL 61 hydrochloride
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 30 mg/mL
Smiles
CCN1C2=C (C=C (C=C2) CNCC3=CC=CC=C3OC) C4=CC=CC=C41.Cl
Molecular Formula
C23H25ClN2O
Molecular Weight
380.9104
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
9H-Carbazole-3-methanamine, 9-ethyl-N-[ (2-methoxyphenyl) methyl]-, hydrochloride (1:1)
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