Stat6 rabbit pAb
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010],
Product Specifications
Background
Synonyms
STAT6; Signal transducer and activator of transcription 6; IL-4 Stat
Gene ID
6778
UniProt
P42226
Cellular Locus
Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat,Monkey
Reactivity
Human; Mouse; Rat; Monkey
Immunogen
The antiserum was produced against synthesized peptide derived from human STAT6. AA range:608-657
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, IHC, IF, ELISA
Validated Applications
WB,IHC,IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Molecular Weight
94kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES7303-1.pdf
Observed Molecular Weight
94 kD
Subcellular Location
Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
Other Product Names
STAT6; Signal transducer and activator of transcription 6; IL-4 Stat
Gene ID (Human)
6778
SwissProt (Human)
P42226
Available Sizes
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