BLU9931

BLU9931 (BLU-9931) is a potent, selective, irreversible inhibitor of FGFR4 with IC50 of 3 nM, shows much weaker activity for FGFR1 (IC50=591 nM), FGFR2 (IC50=493 nM) and FGFR3 (IC50=150 nM) ; potently and selectively inhibits FGFR4 signaling and cell proliferation in HCC cell lines with an activated FGFR4 signaling pathway (Huh-7 cell IC50=110 nM, JHH-7 IC50=20 nM) ; shows remarkable antitumor activity in mice bearing HCC tumor xenograft that overexpresses FGF19.Lung Cancer Phase 1 Clinical.