RG7713
RG7713 (RO5028442, RG-7713) is a potent, highly selective, brain-penetrant vasopressin 1a (hV1a receptor) antagonist with Ki of 1 nM, shows no activiity on hV2 receptor (Ki>30 uM) ; displays moderate mouse affinity and excellent selectivity versus hV2 and hOT receptors.Other Indication Phase 1 Clinical (In Vitro) :RG7713 (RO5028442) (compound 8) has excellent binding in and functional affinity for hV1a, moderate mouse affinity, and excellent selectivity versus human V2 (hV2) and human oxytocin (hOT) receptors. RG7713 (RO5028442) shows high solubility. RG7713 (RO5028442) is found to be highly selective against a panel of 89 targets. Finally, RG7713 (RO5028442) is identified as a suitable compound for clinical studies.
Product Specifications
CAS Number
920022-47-5
Product Name Alternative
RO-5028442 | RG-7713
Purity
>98% (HPLC)
Solubility
DMSO: 10 mM (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C (C1=CN (CCN (C) C) C2=C1C=CC (Cl) =C2) N3CCC4 (CC3) OCC5=C4C=CC=C5
Molecular Formula
C25H28ClN3O2
Molecular Weight
437.97
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(6-Chloro-1- (2- (dimethylamino) ethyl) indol-3-yl) -spiro (1H-isobenzofuran-3,4'-piperidine) -1'-yl-methanone
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