Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Sanggenon C

Product Specifications

UNSPSC Description

Sanggenon C, a flavonoid, exerts protective effects against cardiac hypertrophy and fibrosis via suppression of the calcineurin/NFAT2 pathway. Sanggenon C inhibits mitochondrial fission to induce apoptosis by blocking the ERK signaling pathway. Sanggenon C inhibits inducible nitric oxide synthase expression in RAW264.7 cells, and TNF-α-stimulated cell adhesion and VCAM-1 expression, by suppressing NF-κB activity. Sanggenon C possesses antioxidant, anti-inflammatory and antitumor activities[1][2].

Target Antigen

Apoptosis; ERK; NF-κB; Phosphatase

Type

Natural Products

Related Pathways

Apoptosis;MAPK/ERK Pathway;Metabolic Enzyme/Protease;NF-κB;Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/sanggenon-c.html

Purity

98.50

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C/C(C)=C/C[C@](C1=CC=C(O)C=C1O2)(OC3=CC(O)=C([C@@H](C=C(C)C[C@@H]4C(C=CC(O)=C5)=C5O)[C@@H]4C(C(C=CC(O)=C6)=C6O)=O)C(O)=C3C7=O)[C@]27O

Molecular Weight

708.71

References & Citations

[1]Xiao L, et al. Sanggenon C protects against pressure overload induced cardiac hypertrophy via the calcineurin/NFAT2 pathway. Mol Med Rep. 2017 Oct;16(4):5338-5346.|[2]Xiao-Jie Chen, et al. Sanggenon C Suppresses Tumorigenesis of Gastric Cancer by Blocking ERK-Drp1-Mediated Mitochondrial Fission. J Nat Prod. 2022 Oct 28;85(10):2351-2362.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture and light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-N0617/Sanggenon-C-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-N0617/Sanggenon-C-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

80651-76-9

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

1-(Phenylsulfonyl)-3-indolecarboxaldehyde
sc-222633 1 g

1-(Phenylsulfonyl)-3-indolecarboxaldehyde

Ask
View Details
Sin (m):293T Lysate
sc-123554 100 µg/200 µL

Sin (m):293T Lysate

Ask
View Details
Rat Ketone Body (KB) ELISA Kit
MBS3809439-01 48 Well

Rat Ketone Body (KB) ELISA Kit

Ask
View Details
Rat Ketone Body (KB) ELISA Kit
MBS3809439-02 96 Well

Rat Ketone Body (KB) ELISA Kit

Ask
View Details
Rat Ketone Body (KB) ELISA Kit
MBS3809439-03 5x 96 Well

Rat Ketone Body (KB) ELISA Kit

Ask
View Details
Rat Ketone Body (KB) ELISA Kit
MBS3809439-04 10x 96 Well

Rat Ketone Body (KB) ELISA Kit

Ask
View Details