2-Fluoroadenosine

2-Fluoroadenosine (2FA) is a nucleoside analogue. 2-Fluoroadenosine has antiparasite activity with EC50 value of 0.842 mM for Cryptosporidium parvum. 2-Fluoroadenosine has a highly specific structural basis for MtADK. 2-Fluoroadenosine is commonly used in the study of parasitic conditions[1][2].

Product Specifications

CAS Number

[146-78-1]

Product Name Alternative

2FA

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Parasite

Type

Biochemical Assay Reagents

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/2-fluoroadenosine.html

Purity

99.82

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@@H](O)[C@H](N2C(N=C(F)N=C3N)=C3N=C2)O[C@@H]1CO

Molecular Formula

C10H12FN5O4

Molecular Weight

285.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Arai T, et al. In vitro assessment of anticryptosporidial efficacy and cytotoxicity of adenosine analogues using a SYBR Green real-time PCR method. J Antimicrob Chemother. 2011 Mar;66 (3) :560-3. |[2]Reddy MCM, et al. High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme. J Biol Chem. 2007 Sep 14;282 (37) :27334-27342.