EBE-A22
EBE-A22 is a derivative of PD 153035. EBE-A22, has no effect on EGF-R TK but maintains a high cytotoxic profile. EBE-A22 binds to DNA and behave as typical intercalating agents. EBE-A22 unwinds supercoiled plasmid, stabilizes duplex DNA against heat denaturation, and produces negative CD and ELD signals, as expected for an intercalating agent. EBE-A22, but not PD153035, interacts preferentially with GC-rich sequences and discriminates against homooligomeric runs of A and T which are often cut more readily by the enzyme in the presence of the drug compared to the control.
Product Specifications
CAS Number
229476-53-3
Product Name Alternative
EBE-A22 | EBE A22 | EBEA22
Purity
>98% (HPLC)
Solubility
DMSO : 50 mg/mL 133.61 mM; H2O : < 0.1 mg/mL
Smiles
CN (c1cc (ccc1) Br) c1ncnc2cc (c (cc12) OC) OC
Molecular Formula
C17H16BrN3O2
Molecular Weight
374.23
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N- (3-bromophenyl) -6,7-dimethoxy-N-methylquinazolin-4-amine
Available Sizes
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