Icaritin
Icaritin is an oral traditional Chinese medicine, derived from barrenwort, which targets the estrogen receptor α36. IC50 values for Icaritin are 8,13 and 18 μM for K562, CML-CP and CML-BC cells respectively. Icaritin inhibits the invasion and epithelial-to-mesenchymal transition of glioblastoma cells by targeting EMMPRIN via PTEN/AKt/HIF-1α signalling. Icaritin suppresses hepatocellular carcinoma initiation and malignant growth through the IL-6/Jak2/Stat3 pathway. Icaritin activates JNK-dependent mPTP necrosis pathway in colorectal cancer cells.
Product Specifications
CAS Number
118525-40-9
Product Name Alternative
Icaritin
Purity
>98% (HPLC)
Solubility
DMSO : 14 mg/mL 38.00 mM
Smiles
CC (=CCc1c (cc (c2c1oc (c (c2=O) O) c1ccc (cc1) OC) O) O) C
Molecular Formula
C21H20O6
Molecular Weight
368.38
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3,5,7-Trihydroxy-2- (4-methoxyphenyl) -8- (3-methyl-2-buten-1-yl) -4H-1-benzopyran-4-one
Available Sizes
Frequently Asked Questions
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